Apamin, a blocker of the calcium-activated potassium channel, induces neurodegeneration of Purkinje cells exclusively.
نویسندگان
چکیده
Following acute intracerebroventricular injections of 1 ng of apamin and chronic apamin infusion (0.4 ng/microl, 0.5 microl/h, 14 days), the rat brains exhibited bilateral damage only in the cerebellum. The argyrophilic cells were Purkinje cells in copula pyramis, flocculus, paraflocculus, and paramedian lobules. These data demonstrate that the inactivation of small conductance Ca2+-activated K+ channels by apamin induces a non-limbic neurodegeneration.
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ورودعنوان ژورنال:
- Brain research
دوره 778 2 شماره
صفحات -
تاریخ انتشار 1997